Research Article
VDR Gene Polymorphisms in Healthy Individuals with Family History of Premature Coronary Artery Disease
Table 2
Genotypes frequencies of TaqI, ApaI, and FokI polymorphisms.
| | Genotypes | All
(%) | Study population with FH of P-CAD
(%) | Control group
(%) | valuea |
| | TaqI (rs731236) | 845 (100) | 386 (45.68) | 459 (54.32) | | | AA | 340 (40.24) | 152 (39.38) | 188 (40.96) | 0.896 | | AG | 389 (46.04) | 180 (46.63) | 209 (45.53) | | | GG | 116 (13.73) | 54 (13.99) | 62 (13.51) | | | valueb | 0.778 | 0.951 | 0.746 | |
| | ApaI (rs7975232) | 842 (100) | 386 (45.84) | 456 (54.16) | | | CC | 222 (26.37) | 93 (24.09) | 129 (28.29) | 0.348 | | AC | 409 (48.57) | 196 (50.78) | 213 (46.71) | | | AA | 211 (25.06) | 97 (25.13) | 114 (25.00) | | | valueb | 0.411 | 0.758 | 0.167 | |
| | FokI (rs2228570) | 845 (100) | 386 (45.68) | 459 (54.32) | | | AA | 173 (20.47) | 95 (24.61) | 78 (16.99) | 0.024 | | AG | 428 (50.65) | 186 (48.19) | 242 (52.72) | | | GG | 244 (28.88) | 105 (27.20) | 139 (30.28) | | | valueb | 0.557 | 0.484 | 0.116 | |
|
|
a value of Pearson’s chi-square test. b value of chi-squared test for HWE. |
