The Diagnostic Value of Serum PIVKA-II Alone or in Combination with AFP in Chinese Hepatocellular Carcinoma Patients

Table 2

Diagnostic accuracy of the AFP and PIVKA-II in HCC.

	Se (%)	Sp (%)	PPV (%)	NPV (%)	Accuracy (%)	AUC (95% CI)	Kappa
HCC vs. all controls
AFP	68.8	87.6	94.2	52.7	74.5	0.79 (0.74-0.84)	0.48
PIVKA-II	89.0	91.7	96.5	76.4	89.7	0.90 (0.87-0.94)	0.76
AFP + PIVKA-II	95.1	83.3	93.6	87.0	91.9	0.89 (0.85-0.93)	0.80
HCC vs. LC
AFP	68.8	83.3	95.5	34.2	71.5	0.76 (0.70-0.82)	0.33
PIVKA-II	89.0	90.0	97.9	61.4	89.2	0.89 (0.85-0.94)	0.67
-II	95.1	76.7	95.4	75.4	96.2	0.85 (0.78-0.92)	0.71

Se: sensitivity; Sp: specificity; PPV: positive predictive value; NPV: negative predictive value; AUC: area under the curve; CI: confidence interval; AFP: alpha-fetoprotein; PIVKA-II: prothrombin induced by vitamin K absence II; LC: HBV-related liver cirrhosis.