Disease Markers / 2021 / Article / Tab 1

Research Article

The Role, Function, and Mechanism of Long Intergenic Noncoding RNA1184 (linc01184) in Colorectal Cancer

Table 1

Regulatory ncRNAs associated with CRC.

Regulatory ncRNAsCytobandExpressionMode of action and references

MicroRNAs (miRNAs)
miR-34a1p36.22DecreasedRegulates p53 gene expression [8]
miR-61011p14.1DecreasedTargets hepatoma-derived growth factor (HDGF) [9]
miR-18718q12.2DecreasedTargets transforming growth factor beta (TGF-β) [10]
miR-374aXq13.2DecreasedReducing cyclin D1 (CCND1) to inactivate the PI3K/Akt pathway [11]
miR-363-3pXq26.2DecreasedInhibits epithelial-to-mesenchymal transition (EMT) [12]
miR-15a/1613q14.2DecreasedModulates the expression of genes controlling cell cycle progression [13]
Long or large noncoding RNAs (lncRNAs)
Colorectal cancer-associated lncRNA (CCAL)3q29ElevatedActivates Wnt signaling [14]
Colon cancer-associated transcript-1-long isoform (CCAT1-L)8q24.21ElevatedRegulates chromatin interactions at v-MYC avian myelocytomatosis viral oncogene homolog (MYC) [15]
Colorectal neoplasia differentially expressed (CRNDE)16q12.2ElevatedResponds to epidermal growth factor receptor (EGFR) signaling [16]
HOX transcript antisense intergenic RNA (HOTAIR)12q13.13ElevatedFunctions as a positive moderator of EMT [17]
lincRNA-p216p21.2DecreasedActivated by p53 and modulates heterogeneous nuclear ribonucleoprotein K (hnRNP-K) [18]
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)11q13.1ElevatedPromotes EMT and activates Wnt signaling [19]
Maternally expressed gene 3 (MEG3)14q32DecreasedServe as p53 regulators [20]
H1911p15.5ElevatedActs as precursor of miR-675 to regulate retinoblastoma gene expression and participates EMT [21]