High Expression of JMJD4 Is a Potential Diagnostic and Prognostic Marker of Renal Cell Carcinoma

Table 4

Cox regression analyses of clinical characteristics associated with overall survival.

Characteristics	Total ()	Univariate analysis		Multivariate analysis
		Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
T stage	539
T1 & T2	349	Reference
T3 & T4	190	3.228 (2.382-4.374)	<0.001	1.869 (1.171-2.983)	0.009
Histologic grade	531
G1 & G2	249	Reference
G3 & G4	282	2.702 (1.918-3.807)	<0.001	1.704 (1.037-2.801)	0.036
JMJD4	539
Low	270	Reference
High	269	1.466 (1.084-1.983)	0.013	1.563 (1.055-2.316)	0.026
N stage	257
N0	241	Reference
N1	16	3.453 (1.832-6.508)	<0.001	1.678 (0.819-3.438)	0.157
M stage	506
M0	428	Reference
M1	78	4.389 (3.212-5.999)	<0.001	2.950 (1.832-4.750)	<0.001
Age	539
≤60	269	Reference
>60	270	1.765 (1.298-2.398)	<0.001	1.684 (1.095-2.590)	0.018
Gender	539
Female	186	Reference
Male	353	0.930 (0.682-1.268)	0.648