Associations of Genetic Polymorphisms of mTOR rs2295080 T/G and rs1883965 G/A with Susceptibility of Urinary System Cancers

Table 1

Study characteristics of mTOR rs2295080 T/G and rs1883965 G/A variants in the current analysis.

Author	Year	Origin	Cancer	Ethnicity	Type	Source of control	Case	Control	Case			Control			HWE	Method
rs2295080 T/G									GG	GT	TT	GG	GT	TT
Cao	2012	China	KIRC	East Asian	Urinary cancer	Hospital-based	710	760	38	218	454	45	277	438	0.891	TaqMan
Chen	2012	China	PRAD	East Asian	Urinary cancer	Hospital-based	666	708	28	209	429	36	259	413	0.573	TaqMan
Huang	2012	China	ALL	East Asian	Blood cancer	Hospital-based	417	554	23	140	254	21	180	353	0.549	TaqMan
Li	2013	China	PRAD	East Asian	Urinary cancer	Population-based	1004	1051	40	311	653	52	382	617	0.468	TaqMan
Xu	2013	China	GCA	East Asian	Digestive cancer	Hospital-based	753	854	25	246	482	52	305	497	0.569	TaqMan
Wang	2015	China	GCA	East Asian	Digestive cancer	Hospital-based	1002	1003	40	394	568	41	355	607	0.221	TaqMan
Xu	2015	China	CRC	East Asian	Digestive cancer	Hospital-based	737	777	30	225	482	45	273	459	0.602	TaqMan
Zhao	2015	China	ALL	East Asian	Blood cancer	Hospital-based	133	296	15	50	68	12	111	173	<0.001	PCR-RFLP
Zhao	2015	China	AML	East Asian	Blood cancer	Hospital-based	47	296	6	14	27	12	111	173	<0.001	PCR-RFLP
Zhu	2015	China	ESCC	East Asian	Digestive cancer	Population-based	1113	1113	49	390	674	49	362	702	0.788	TaqMan
Zhang	2015	China	KIRC	East Asian	Urinary cancer	Hospital-based	710	760	38	218	454	45	277	438	0.891	TaqMan
Zhao	2016	China	Breast	East Asian	Breast cancer	Hospital-based	560	583	12	197	351	26	212	345	0.358	Sequenom
Liu	2017	China	PRAD	East Asian	Urinary cancer	Hospital-based	413	807	32	145	236	37	316	454	0.052	TaqMan
Wen	2017	China	TCA	East Asian	Others	Population-based	560	500	24	170	366	29	176	295	0.686	TaqMan
Zhao	2017	China	GCA	East Asian	Digestive cancer	Population-based	283	271	15	90	178	11	86	174	0.927	TaqMan
Qi	2017	China	GCA	East Asian	Digestive cancer	Hospital-based	574	912	101	279	194	174	441	297	0.651	TaqMan
Bizhani	2018	Iran	BLCA	West Asian	Urinary cancer	Population-based	235	254	80	90	65	152	76	26	0.001	PCR-RFLP
Chen	2019	China	Breast	East Asian	Breast cancer	Population-based	530	480	19	201	310	37	198	245	0.730	TaqMan
rs1883965 G/A									AA	AG	GG	AA	AG	GG
He	2013	China	GCA	East Asian	Digestive cancer	Population-based	1125	1196	10	188	927	6	165	1025	0.817	TaqMan
Zhu	2013	China	ESCC	East Asian	Digestive cancer	Population-based	1123	1121	6	209	908	7	174	940	0.732	TaqMan
Li	2013	China	PRAD	East Asian	Urinary cancer	Population-based	1004	1051	8	153	843	7	154	890	0.904	TaqMan
Liu	2014	China	Liver	East Asian	Digestive cancer	Hospital-based	1048	1052	2	165	881	10	160	882	0.365	TaqMan

ALL: acute lymphoblastic leukemia; BLCA: bladder cancer; CRC: colorectal cancer; AML: acute myeloid leukemia; ESCC: esophageal squamous cell carcinoma; GCA: gastric cancer; HWE: Hardy-Weinberg equilibrium of control; PRAD: prostate cancer; TCA: thyroid cancer; KIRC: kidney renal clear cell carcinoma.