LTB4 Promotes Acute Lung Injury via Upregulating the PLCε-1/TLR4/NF-κB Pathway in One-Lung Ventilation

Figure 1

OLV induces inflammatory activation and lung permeability changes. (a, b) H&E staining detected the pathology of lung tissues in OLV and control rats. (c) The lung W/D ratio between OLV and control rats was calculated according to the formula . (d) The PMN/WBC ratio of BALF in OLV and control rats was calculated. (e–k) ELISA performed to examine the levels of inflammation mediators (GM-CSF, IL-1β, IL-8, KC, MCP-1, MIP-2, and TNF-α) between the OLV group and control rats. (l–o) Western blot detected the protein levels of Bcl-2, Bax, caspase 3, MLCK, VE-cadherin, occludin, and ZO-1 in OLV and control rats. , , and .

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