G Protein-Coupled Receptor Kinase 4 Is a Novel Prognostic Factor in Hepatocellular Carcinoma

Table 2

Univariate Cox regression analysis of factors associated with survival.

Variable	HR (95% CI)	value
Age	0.99 (0.97, 1.01) 0.2403	0.24
Cirrhosis, no vs. yes	0.94 (0.67, 1.31) 0.7015	0.70
Tumor diameter	1.06 (1.03, 1.10)	0.00
Venous invasion, no vs. yes	2.39 (1.63, 3.49)	0.00
Tumor type, nodular vs. diffuse	2.97 (2.06, 4.27)	0.00
Number of tumors, solitary vs. multiple	2.39 (1.60, 3.58)	0.00
Anatomic location, left vs. right	0.69 (0.49, 0.99) 0.0444	0.04
T stage
2 vs. 1	1.19 (0.68, 2.08) 0.5447	0.54
3 vs. 1	4.40 (2.85, 6.81)	0.00
4 vs. 1	10.87 (5.13, 23.03)	0.00
Tumor GRK4
1+ vs. negative	0.68 (0.43, 1.05) 0.0837	0.08
2+ vs. negative	0.60 (0.37, 0.98) 0.0413	0.04
3+ vs. negative	0.28 (0.15, 0.52)	0.00
Peritumor GRK4
1+ vs. negative	1.74 (0.56, 5.40) 0.3397	0.34
2+ vs. negative	1.42 (0.60, 3.34) 0.4268	0.43
3+ vs. negative	1.70 (0.74, 3.91) 0.2125	0.21
Grade
2 vs. 1	1.10 (0.65, 1.87) 0.7218	0.72
3 vs. 1	1.40 (0.71, 2.75) 0.3293	0.33