G Protein-Coupled Receptor Kinase 4 Is a Novel Prognostic Factor in Hepatocellular Carcinoma

Table 3

Multivariate Cox regression analysis of factors associated with survival.

Variable	Multivariate
	HR (95% CI)	value
Tumor diameter	1.04 (0.96, 1.13)	0.31
Venous invasion, no vs. yes	1.07 (0.52, 2.20)	0.85
Tumor type, diffuse vs. nodular	2.10 (0.88, 5.00)	0.09
Number of tumors, solitary vs. multiple	0.89 (0.41, 1.94)	0.77
Anatomic location, left vs. right	0.94 (0.57, 1.56)	0.82
T stage
1 vs. 3	0.77 (0.32, 1.85)	0.04
2 vs. 3	2.81 (1.02, 7.72)	0.01
4 vs. 3	10.75 (2.57, 44.97)	0.02
Tumor GRK4
1+ vs. negative	0.50 (0.26, 0.97)	0.04
2+ vs. negative	0.53 (0.26, 1.11)	0.09
3+ vs. negative	0.28 (0.12, 0.64)	0.00