Research Article

Identification of CXCR4 Upregulation in Diffuse Large B-Cell Lymphoma Associated with Prognostic Significance and Clinicopathological Characteristics

Figure 2

GSEA Gene Ontology (GO) analysis showed that CXCR4-related genes were enriched in (a) biological process (BP), (b) cellular component (cc), and (c) molecular function (MF). (d) GSEA C2 curated gene sets analysis. (e) Protein-protein interaction network of CXCR4 by the STRING website (left). Selected 30 hub genes (C3, CCR7, AURKB, CDC45, CDC6, GNG7, S1PR1, CENPM, CX3CR1, EXO1, KIF4A, MCM10, ADRA2A, CCL21, CNR1, CXCL13, DRD4, GPR183, HRAS, PNOC, FOXM1, HJURP, SYK, CDT1, SELL UQCR10, CDCA5, HIST1H2BD, HNRNPA2B1, HNRNPH1) as center nodes of the interaction network are shown in the right table (red: upregulation; blue: downregulation). (f) GO and KEGG analysis of 30 hub genes by KOBAS 3.0.
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