Identification of CXCR4 Upregulation in Diffuse Large B-Cell Lymphoma Associated with Prognostic Significance and Clinicopathological Characteristics

Figure 6

The forkhead box O (FOXO) protein family regulates the expression of genes in cellular physiological events including apoptosis, tumor angiogenesis, glucose metabolism, oxidative stress resistance, and DNA damage repair. PI3K-Akt signaling pathway is activated in response to CXCR4/CXCL12 activation. Then, FOXO proteins are phosphorylation by the serine/threonine kinase (AKT)/protein kinase B (PKB). Phosphorylated FOXOs result in the export of FOXOs from the nucleus to the cytoplasm, thereby decreasing expression of FOXO target genes. Other posttranslational modifications of FOXO include methylation, acetylation, ubiquitylation, and glycosylation.