The Effect of Artificial Liver Support System on Prognosis of HBV-Derived Hepatorenal Syndrome: A Retrospective Cohort Study

Table 4

Univariate and multivariate Cox regression.

Variates	Univariate cox regression		Multivariate cox regression
	HR (95% CI)	value	HR (95% CI)	value
Age (year)	0.99 (0.99-1.02)	0.329	1.02 (1.00-1.03)	0.069
Male sex	1.01 (0.62-1.63)	0.981	1.24 (0.76-2.03)	0.396
Degree of HE
Without HE	Ref.
I	1.57 (0.92-2.66)	0.096
II	1.42 (0.70-2.90)	0.329
III	2.40 (1.28-4.52)	0.007
IV	2.67 (1.69-4.21)	<0.001
Ascitic (%)
Grade 1	Ref.
Grade 2	0.41 (0.19-0.86)	0.019
Grade 3	0.48 (0.23-1.00)	0.051
Missing data	0.46 (0.21-0.99)	0.049
MAP (mmHg)	0.99 (0.98-1.00)	0.180
HR	1.02 (1.01-1.03)	<0.001
INR	1.82 (1.56-2.02)	<0.001	1.61 (1.37-1.89)	<0.001
WBC (10^9/L)	1.09 (1.06-1.12)	<0.001	1.03 (0.99-1.07)	0.104
Neutrophil (%)	1.05 (1.04-1.07)	<0.001	1.03 (1.01-1.05)	0.003
Albumin (g/L)	0.98 (0.94-1.01)	0.168	0.98 (0.94-1.02)	0.257
Globulin (g/L)	1.01 (0.99-1.03)	0.463
ALT (U/L)	1.00 (1.00-1.00)	0.003
AST (U/L)	1.00 (1.00-1.00)	0.001
Hemoglobin (g/L)	1.00 (1.00-1.01)	0.219
Cystatin C (mg/L)	1.25 (1.05-1.49)	0.012
Urea (mmol/L)	1.01 (1.00-1.02)	0.012
Creatinine (mg/dL)	1.00 (1.00-1.00)	0.046
Serum bilirubin (mg/dL)	1.00 (1.00-1.00)	<0.001	1.00 (1.00-1.00)	0.104
GGT (U/L)	1.00 (1.00-1.00)	0.952
Potassium (mmol/L)	0.99 (0.96-1.02)	0.535
Sodium (mmol/L)	0.96 (0.94-0.98)	<0.001
MELDs	1.10 (1.07-1.12)	<0.001
iMELD	1.08 (1.06-1.10)	<0.001
CTP	1.48 (1.32-1.67)	<0.001
CLIF-ACLFs	1.08 (1.06-1.10)	<0.001
CLIF-SOFAs	1.22 (1.16-1.28)	<0.001
COSSH-ACLFs	1.47 (1.35-1.60)	<0.001
Organ failure
Liver failure	2.07 (1.40-3.07)	<0.001
Coagulation failure	2.87 (1.99-4.13)	<0.001
Cerebral failure	2.27 (1.55-3.31)	<0.001
With ALSS	0.60 (0.39-0.95)	0.027	0.59 (0.38-0.94)	0.025