The Association of Long-Term Use of Proton Pump Inhibitors and Histamine H₂ Receptor Antagonists with Clinical Complications in Patients with Severe Sepsis

Table 3

Use of other drugs among sepsis patients.

Characteristic	Total (%)	PPIs (in ICU) (%)	H2 blockers (in ICU) (%)	value
ACE (angiotensin-converting enzyme) inhibitors	72219 (37.43)	59234 (38.34)	12985 (37.11)	0.056
NSAIDs (nonsteroidal anti-inflammatory drugs)	43105 (27.58)	27880 (25.55)	15225 (29.57)	0.07
Stations	79281 (38.76)	61255 (40.11)	18056 (37.23)	0.48
Mean systolic blood pressure (mmHg) (SD)	135.46 (19.07)	134.25 (19.11)	136.37 (19.05)	<0.001
Mean diastolic blood pressure (mmHg) (SD)	75.23 (11.29)	76.23 (11.45)	75.11 (11.12)	0.21
Mean GFR (glomerular filtration rate) (ml/min/1.73 m^2) (SD)	73.56 (20.11)	72.66 (21.11)	74.87 (19.39)	0.014
Median high-density lipoprotein (mg/dl) (IQR)	41.77 (35.00-50.00)	41.33 (35.00-50.00)	42.87 (35.00-50.00)	0.46
Median low-density lipoprotein (mg/dl), (IQR)	107.22 (85.0-129.1)	106.66 (45.0-129.0)	108.56 (87.0-129.0)	0.002
Median (IQR) HbA1C	6.3 (5.1-6.1)	6.2 (5.5-6.9)	6.4 (5.5-7.1)	<0.001