The Association of Long-Term Use of Proton Pump Inhibitors and Histamine H2 Receptor Antagonists with Clinical Complications in Patients with Severe Sepsis
Table 6
Outcome controls: positive and negative.
Outcomes
Events per 100 (95% CI)
Excess (95% CI)
Hazard ratio
PPI
H2 blockers
Cox
Fine and gray
Acute kidney injury
10.57 (10.02-12.97)
7.67 (7.04-9.96)
13.07 (1.08 to 27.45)
1.07 (1.01-1.35)
1.15 (1.06-1.23)
Chronic kidney disease
11.94 (9.56-14.86)
8.56 (7.02-10.11)
14.97 (1.05 to 27.97)
1.05 (1.05-1.56)
1.06 (1.86-1.56)
Transportation-related death
0.31 (0.24-0.41)
0.37 (0.18-0.45)
-0.31 (-2.98 to 2.67)
0.95 (0.43-2.38)
0.93 (0.41-2.71)
Peptic ulcer disease-related death
0.03 (0.01-0.05)
0.07 (0.03-0.12)
-0.41 (-2.19 to 0.18)
0.41 (0.17-1.79)
0.38 (0.12-1.65)
: positive control defined by ICD-9 584. : negative outcome defined by ICD-10 V00-V99. : negative outcome defined by CD-10 K211, K226, K20, and K250-K289.
