Research Article

Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying MicroRNA-29a Improves Ovarian Function of Mice with Primary Ovarian Insufficiency by Targeting HMG-Box Transcription Factor/Wnt/β-Catenin Signaling

Figure 2

UCMSC-exosomes can deliver miR-29a into the GCs. (a) Morphology of isolated GCs. (b) Immunofluorescence of GC surface marker (FSHR). (c) miR-29a level in the sham, the POI, the POI+PBS, and the POI+exosome groups. (d) miR-29a level in the control, the cisplatin, and the cisplatin+exosome groups. (e) miR-29a level in UCMSCs, UCMSC-exosomes, and UCMSC-exosome-treated GCs. (f) UCMSCs were treated with RNase A or RNase A in combination with Triton X-100. RT-qPCR was conducted to measure the miR-29a level. .