Research Article

Downregulation of MCF2L Promoted the Ferroptosis of Hepatocellular Carcinoma Cells through PI3K/mTOR Pathway in a RhoA/Rac1 Dependent Manner

Figure 2

Downregulation of MCF2L enhances HCC cell death induced by sorafenib. (a) The mRNA (left panel) and protein (right panel) levels of MCF2L in indicated stable cell line. (b) MTT assay showed that downregulation of MCF2L enhances HCC cell death induced by sorafenib. (c) The representative image (left panel) and quantitative assay (right panel) of colony formation showed that downregulation of MCF2L enhances HCC cell death induced by sorafenib. (d) The representative images (left panel) and quantitative assay (right panel) of Brdu assay. (e) The in vivo tumorigenesis assay showed downregulation of MCF2L inhibits the tumorigenesis under the treatment of sorafenib .
(a)
(b)
(c)
(d)
(e)