Research Article

Downregulation of MCF2L Promoted the Ferroptosis of Hepatocellular Carcinoma Cells through PI3K/mTOR Pathway in a RhoA/Rac1 Dependent Manner

Figure 3

MCF2L is involved in ferroptosis of HCC cell. (a) The viability of MCF2L-konckdown cells can be rescued by ferroptosis inhibitor Ferrostatin-1, but not pan-caspase inhibitor Z-VAD-FMK, neccroptosis inhibitor necrosulfonamide, and autophagy inhibitor 3-MA using Huh7 (left panel) and MHCC97H (right panel) cell. (b) The relative Iron levels in indicated cells induced by sorafenib. (c) The relative levels of GSH in indicated cells induced by sorafenib. (d) The relative levels of ROS in indicated cells induced by sorafenib. (e) The relative levels of MDA in indicated cells induced by sorafenib. .
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