Partial-Methylated HeyL Promoter Predicts the Severe Illness in Egyptian COVID-19 Patients

Figure 3

(I) Reference sequence (Genbank) span from -239 to -365 upstream TSS; (II) logos sequencing analysis of transcription factors binding sites in the HeyL promoter for samples obtained from COVID-19 patients and control subjects compared to the consensus sequence in reference sequence showing the amount of information at each position in each motif at -axis for (a) PARP1 binding motif, (b) FRE binding motif, (c) CAGA-Box binding motif, (d) E-Box binding motif, (e) ZFX binding motif, (f) KLF binding motif, and (g) VDRE binding motif; (III) comparison between the methylation status of binding sites in COVID-19 patients (upper) and control healthy subjects (lower). Symbol of Nucleotides: G = guanine; A = adenine; C = cytosine; T = thymine; R = purine (A or G); Y = pyrimidine (C or T); N = any nucleotide Methylated cytosine CpG (blue underlined), unmethylated cytosine (TG) (red underlined).