Perisciatic Nerve Dexmedetomidine Alleviates Spinal Oxidative Stress and Improves Peripheral Mitochondrial Dynamic Equilibrium in a Neuropathic Pain Mouse Model in an AMPK-Dependent Manner

Figure 1

Impact of DEX on the pain thresholds among mice with CCI. (a) Gradually decreasing threshold for CCI-induced murine mechanical pain. (b) Effect of different doses of DEX on the mechanical pain threshold in CCI mice. (c) Effects of 25 μg/kg DEX and AMPK inhibitor compound C on mechanical pain threshold in mice with CCI at various times. (d) CCI induced progressive decrease of thermal latency. (e) Effects of different doses of DEX on heat latency among mice with CCI. (f) Effects of 25 μg/kg DEX and AMPK inhibitor compound C on the thermal latency in CCI mice at different times. Data are (); , , and versus negative control group; ^#, ^##, and ^### versus CCI group; ^$, ^$$, and ^$$$ CCI+DEX versus CCI+DEX+CC group.

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