U-Shape Relationship between Plasma Leucine Level and Mortality in the Intensive Care Unit

Table 3

COX univariate and multivariable analysis of factors for predicting mortality in the initiation cohort.

	Univariate		Multivariable		Multivariable^†
	HR (95% CI)	value	HR (95% CI)	value	HR (95% CI)	value
Leucine
Leucine 109-174 μM (reference)
	2.16 (1.30-3.59)	0.003	2.03 (1.22-3.37)	0.006	2.06 (1.22-3.47)	0.007
	1.66 (1.10-2.51)	0.015	1.52 (1.01-2.31)	0.043	0.95 (0.60-1.50)	0.828
Age (years)	1.02 (1.00-1.03)	0.046
APACHE II score	1.12 (1.09-1.16)	<0.001	1.08 (1.06-1.11)	<0.001	1.09 (1.05-1.12)	<0.001
SOFA score	1.23 (1.17-1.28)	<0.001	1.14 (1.07-1.21)	<0.001	1.18 (1.11-1.24)	<0.001
COPD	0.27 (0.09-0.86)	0.027
C-reactive protein (log)	2.21 (1.62-3.01)	<0.001	2.26 (1.65-3.10)	<0.001
Cholesterol (mg/dL)	0.99 (0.98-0.99)	<0.001	0.98 (0.98-0.99)	<0.001
Albumin (g/dL)	0.392 (0.29-0.53)	<0.001	0.41 (0.29-0.54)	<0.001
Prealbumin (mg/dL)	0.92 (0.89-0.95)	<0.001	0.92 (0.89-0.95)	<0.001
Transferrin (mg/dL)	0.99 (0.98-0.99)	<0.001	0.98 (0.98-0.99)	<0.001

APACHE: acute physiology and chronic health evaluation; CI: confidence interval; COPD: chronic obstructive pulmonary disease; HR: hazard ratio; SOFA: sequential organ failure assessment. , adjusting for age and COPD. †, adjusting for age, COPD, C-reactive protein, cholesterol, albumin, prealbumin, and transferrin.