Research Article
Alpha-Fetoprotein Ratio Predicts Alpha-Fetoprotein Positive Hepatocellular Cancer Patient Prognosis after Hepatectomy
Table 2
The clinical feature of patients with AFP ratio high and AFP ratio low in 2 cohort.
| | Training cohort | value | Validation cohort | value | | AFP ratio high | AFP ratio low | AFP ratio high | AFP ratio low |
| | Number | 306 | 133 | | 318 | 122 | | | Age | | | 0.406 | | | 0.124 | | Gender | | | | | | | | Male | 254 (83.0) | 120 (90.2) | 0.050 | 275 (86.5) | 112 (91.8) | 0.051 | | Female | 52 (17.0) | 13 (9.8) | | 43 (13.5) | 10 (8.2) | | | Smoking history, (%) | | | | | | | | Yes | 131 (42.8) | 62 (46.6) | 0.460 | 148 (46.5) | 55 (45.1) | 0.783 | | No | 175 (57.2) | 71 (53.4) | | 170 (53.5) | 67 (54.9) | | | Alcohol history, (%) | | | | | | | | Yes | 60 (19.6) | 33 (24.8) | 0.220 | 80 (25.2) | 29 (23.8) | 0.763 | | No | 246 (80.4) | 100 (75.2) | | 238 (74.8) | 93 (76.2) | | | HBsAg, (%) | | | | | | | | Positive | 266 (86.9) | 114 (85.7) | 0.732 | 262 (82.4) | 109 (89.3) | 0.073 | | Negative | 40 (13.1) | 19 (14.3) | | 56 (17.6) | 13 (10.7) | | | Cirrhosis, (%) | | | | | | | | Yes | 298 (97.4) | 128 (96.2) | 0.515 | 316 (99.4) | 117 (95.9) | 0.009 | | No | 8 (2.6) | 5 (3.8) | | 2 (0.6) | 5 (4.1) | | | Child-Pugh score | | | 0.103 | | | 0.090 | | Class | | | | | | | | A | 302 (98.7) | 129 (97.0) | 0.221 | 317 (99.7) | 120 (98.4) | 0.131 | | B | 4 (1.3) | 4 (3.0) | | 1 (0.3) | 2 (1.6) | | | MELD score | | | 0.214 | | | 0.013 | | ALBI score | | | 0.003 | | | 0.056 | | TNM stage, (%) | | | | | | | | IA | 40 (13.1) | 13 (9.8) | 0.319 | 30 (9.4) | 8 (6.6) | 0.334 | | IB | 102 (33.3) | 47 (35.3) | | 118 (37.1) | 37 (30.3) | | | II | 106 (34.6) | 54 (40.6) | | 110 (34.6) | 50 (41.0) | | | IIIA | 23 (7.5) | 11 (8.3) | | 27 (8.5) | 9 (7.4) | | | IIIB | 35 (11.4) | 8 (6.0) | | 33 (10.4) | 18 (14.8) | | | Tumor size (cm) | | | 0.470 | | | 0.459 | | Differentiation, (%) | | | | | | | | Well-moderate | 173 (56.5) | 80 (60.2) | 0.481 | 187 (58.8) | 69 (56.6) | 0.669 | | Poor-undifferentiated | 133 (43.5) | 53 (39.8) | | 131 (41.2) | 53 (43.3) | | | Microscopic vascular invasion, (%) | | | | | | | Yes | 129 (42.2) | 53 (39.8) | 0.652 | 140 (44.0) | 58 (47.5) | 0.507 | | No | 177 (57.8) | 80 (60.2) | | 178 (56.0) | 64 (52.5) | | | Macroscopic vascular invasion, (%) | | | | | | | Yes | 33 (10.8) | 8 (6.0) | 0.115 | 29 (9.1) | 15 (12.3) | 0.320 | | No | 273 (89.2) | 125 (94.0) | | 289 (90.9) | 107 (87.7) | | | Tumor multiplicity, (%) | | | | | | | | Single | 249 (81.4) | 100 (75.2) | 0.140 | 264 (83.0) | 98 (80.3) | 0.508 | | Multiple | 57 (18.6) | 33 (24.8) | | 54 (17.0) | 24 (19.7) | | | AFP before hepatectomy (ng/μl) | | | <0.001 | | | 0.002 | | AFP after hepatectomy (ng/μl) | | | 0.036 | | | 0.029 |
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