Increased Sphingosine Kinase 1 Expression Is Associated with Poor Prognosis in Human Solid Tumors: A Meta-Analysis
Table 2
Summary of the meta-analysis results.
Categories
Cohorts (patients)
HR (95% CI)
(%)
OS (all)
29 (5466)
1.71 (1.45-2.01)
84.3
<0.001
6.45
<0.001
Cancer type
Digestive system
14 (2279)
1.79 (1.39-2.31)
89.0
<0.001
4.50
<0.001
Urinary system
2 (511)
1.49 (1.20-1.84)
0.0
0.998
3.68
<0.001
Reproductive system
2 (1292)
1.71 (0.34-8.64)
64.2
0.095
0.64
0.519
HNC
4 (613)
2.08 (1.48-2.91)
0.0
0.841
4.26
<0.001
LC
4 (301)
2.15 (1.39-3.35)
63.4
0.042
3.41
0.001
BC
3 (470)
1.16 (0.66-2.02)
74.0
0.021
0.51
0.608
Sample size
≥150
12 (3783)
1.45 (1.17-1.80)
88.6
<0.001
3.42
0.001
<150
17 (1683)
1.97 (1.58-2.45)
59.5
0.001
6.07
<0.001
SPHK1-high
≥60%
14 (2209)
2.07 (1.55-2.75)
90.4
<0.001
4.99
<0.001
<60%
15 (3257)
1.44 (1.18-1.76)
66.7
<0.001
3.64
<0.001
Analysis method
Multivariate
17 (3811)
1.65 (1.34-2.04)
79.1
<0.001
4.73
<0.001
Univariate
12 (1655)
1.73 (1.43-2.08)
66.3
0.001
5.75
<0.001
DFS (all)
11 (1839)
1.34 (1.13-1.59)
57.3
0.009
3.36
0.001
All pooled HRs were calculated from random-effect model. HNC: head and neck cancer; LC: lung cancer; BC: breast cancer; OS overall survival; DFS: disease-free survival; HR: hazard ratio; CI: confidence interval; : value for statistical significance based on test; : value for heterogeneity based on test.
