Increased Sphingosine Kinase 1 Expression Is Associated with Poor Prognosis in Human Solid Tumors: A Meta-Analysis
Table 3
Meta-analysis of SPHK1 and clinicopathological features in cancer patients.
Categories
Cohorts (patients)
OR (95% CI)
Age (young vs. old)
21 (4607)
1.47 (0.80-2.70)
94.9
<0.001
1.23
0.217
Gender (male vs. female)
20 (3515)
1.02 (0.87-1.19)F
15.9
0.256
0.24
0.813
Clinical stage (I-II vs. III-IV)
17 (3951)
2.07 (1.39-3.09)
79.6
<0.001
3.56
<0.001
Tumor invasion (T1-T2 vs. T3-T4)
10 (2062)
2.16 (1.47-3.18)
52.8
0.025
3.91
<0.001
Lymph node metastasis (negative vs. positive)
17 (2922)
2.04 (1.71-2.44)F
33.3
0.090
7.88
<0.001
Distant metastasis (negative vs. positive)
12 (2261)
3.16 (2.44-4.09)F
0.0
0.632
8.72
<0.001
Tumor size (small vs. large)
14 (2655)
1.36 (0.85-2.18)
84.8
<0.001
1.28
0.199
All pooled ORs were calculated from random-effect model except for cells marked with (fixedF). denotes value for heterogeneity based on test; denotes value for statistical significance based on test. OR: odds ratio; CI: confidence interval.
