Lack of Association between Epidermal Growth Factor or Its Receptor and Reflux Esophagitis, Barrett’s Esophagus, and Esophageal Adenocarcinoma: A Case-Control Study

Table 4

Gene-gene interaction: +61 A>G EGF (rs4444903) and +142285 G>A EGFR (rs2227983) between the NERD patients and individual subgroups with RE/BE/EAC (), age- and sex-adjusted.

EGF-EGFR interaction	Group 2		RE		RE vs. Group 2; ORadj (95% CI)	value	BE		BE vs. Group 2; ORadj (95% CI)	value	EAC		EAC vs. Group 2; ORadj (95% CI)	value
Reference	38	35.8%	49	30.4%	1.00 (ref.)		26	28.3%	1.00 (ref.)		16	33.3%	1.00 (ref.)
AA-AA	3	2.8%	4	2.5%	0.98 (0.20-4.80)	0.983	5	5.4%	2.22 (0.40-12.38)	0.364	1	2.1%	0.57 (0.04-7.72)	0.676
AA-AG	7	6.6%	21	13.0%	2.31 (0.88-6.08)	0.091	13	14.1%	2.76 (0.83-9.15)	0.096	5	10.4%	3.01 (0.50-18.04)	0.228
AA-GG	26	24.5%	40	24.8%	1.19 (0.61-2.31)	0.604	19	20.7%	1.30 (0.55-3.07)	0.544	10	20.8%	0.99 (0.29-3.36)	0.988
AG-GG	25	23.6%	38	23.6%	1.22 (0.62-2.39)	0.562	19	20.7%	1.19 (0.49-2.88)	0.694	13	27.1%	1.48 (0.46-4.82)	0.514
GG-GG	7	6.6%	9	5.6%	1.11 (0.37-3.34)	0.859	10	10.9%	2.28 (0.65-7.93)	0.195	3	6.3%	2.86 (0.40-20.58)	0.295

Adj: adjusted OR for age and sex; BE: Barrett’s esophagus; CI: confidence interval; EAC: esophageal adenocarcinoma; EGF: epidermal growth factor; EGFR: epidermal growth factor receptor; GERD: gastroesophageal reflux disease group; NERD: non-erosive reflux disease group; OR: odds ratio; RE: reflux esophagitis; reference genotypes EGF-EGFR (AG-AA; AG-AG; GG-AA; GG-AG) according to Upadhyay et al. [27]; Group 2: patients without macroscopical changes of the esophageal mucosa and with/without NERD (including healthy individuals).