Inhibition of DEK Enhances Doxorubicin-Induced Apoptosis and Cell Cycle Arrest in T-Cell Acute Lymphoblastic Leukemia Cells

Figure 3

Knockdown of DEK promotes doxorubicin- (DOX-) induced apoptosis and cell cycle arrest of Jurkat cells. (a, b) Cells were treated with vehicle or DOX for 72 h at 5 days after lentiviral infection, and then, we examined cell apoptosis via flow cytometry. (c–e) Flow cytometry analysis was carried out to examine cell cycle phase distribution of Jurkat cells. (f) Cell viability in SCR and DEK KD groups was detected by CCK-8. Data are expressed as the . , , , and ; shDEK-1 and shDEK-2 vs. SCR or shDEK-1+DOX and shDEK-2+DOX vs. SCR+DOX; . SCR: scramble RNA.

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