Research Article
Construction and Validation of a Risk Prediction Model for Acute Kidney Injury in Patients Suffering from Septic Shock
Table 3
Univariate logistic regression analysis of predictive variables of AKI in the training cohort.
| | Variables | OR | 95% CI | value |
| | Demographic variables | | | | | Age (years) | 1.01 | 1.17-1.89 | 0.340 | | Female, (%) | 1.49 | 0.99-1.02 | <0.001 | | Non-Caucasian, (%) | 0.59 | 0.45-0.77 | <0.001 | | Obesity, (%) | 2.61 | 1.02-1.76 | <0.001 | | Comorbidities, (%) | | | | | Congestive heart failure, (%) | 1.34 | 0.95-1.57 | 0.030 | | Hypertension, (%) | 1.22 | 1.04-1.81 | 0.130 | | Diabetes, (%) | 1.38 | 1.43-4.78 | 0.020 | | Interventions | | | | | Aminoglycoside, (%) | 0.99 | 1.00-1.01 | 0.960 | | Glycopeptide antibiotics, (%) | 0.81 | 1.03-1.06 | 0.130 | | NSAIDs, (%) | 0.96 | 0.97-1.08 | 0.740 | | Stain, (%) | 1.25 | 0.60-1.63 | 0.180 | | ACEI/ARBs, (%) | 1.72 | 0.62-1.06 | <0.001 | | Mechanical ventilation, (%) | 1.87 | 1.41-2.47 | <0.001 | | Scoring systems | | | | | APSIII | 1.00 | 0.73-1.25 | 0.560 | | SAPSII | 1.05 | 0.91-1.71 | <0.001 | | Vital signs | 1.02 | 1.34-2.21 | 0.410 | | Heart rate (beats/minute) | 1.01 | 1.00-1.02 | 0.230 | | Systolic pressure (mmHg) | 1.00 | 0.98-1.01 | 0.700 | | Diastolic pressure (mmHg) | 0.99 | 0.98-1.01 | 0.420 | | Respiratory rate (beats/minute) | 1.00 | 0.97-1.03 | 1.000 | | Temperature (°C) | 0.85 | 0.71-1.02 | 0.090 | | SpO2 (%) | 0.96 | 0.91-1.02 | 0.230 | | Laboratory test | | | | | Anion gap (mmol/l) | 1.00 | 0.94-1.06 | 0.900 | | Bicarbonate (mEq/l) | 1.03 | 0.99-1.07 | 0.130 | | Bilirubin (mg/dl) | 1.07 | 1.03-1.13 | <0.001 | | Creatinine (mg/dl) | 1.25 | 1.05-1.48 | 0.010 | | Chloride (mEq/l) | 0.99 | 0.96-1.01 | 0.190 | | Glucose (mg/dl) | 1.00 | 0.99-1.00 | 0.130 | | Lactate (mmol/l) | 1.07 | 0.96-1.19 | 0.230 | | Platelets (K/Ul) | 1.00 | 0.99-1.01 | 0.730 | | Potassium (mEq/l) | 1.04 | 0.85-1.27 | 0.700 | | PTT (seconds) | 1.00 | 0.99-1.01 | 0.230 | | APTT (seconds) | 0.99 | 0.98-1.00 | 0.050 | | BUN (mg/dl) | 0.99 | 0.98-1.00 | <0.001 | | WBC (K/Ul) | 0.99 | 0.98-1.01 | 0.240 | | Neutrophils (%) | 1.00 | 0.99-1.01 | 0.930 | | Lymphocytes (%) | 1.00 | 0.99-1.01 | 0.310 | | Culture | | | | | Gram positive bacteria, (%) | 1.35 | 1.01-1.81 | 0.050 | | Gram negative bacteria, (%) | 1.04 | 0.71-1.52 | 0.850 |
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CI: confidence interval; OR: odds ratio; NSAIDs: nonsteroidal anti-inflammatory drugs; ACEI: angiotensin-converting enzyme inhibitors; ARBs: angiotensin receptor blockers; APS III: acute physiology score III; SAPS II: simplified acute physiology score II; PTT: prothrombin time; APTT: activated partial thromboplastin time; BUN: blood urea nitrogen; WBC: white blood cell; AKI: acute kidney injury.
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