Research Article

Characterization of Epithelial-Mesenchymal Transition Identifies a Gene Signature for Predicting Clinical Outcomes and Therapeutic Responses in Bladder Cancer

Figure 2

Identification of EMT as the leading risk factor for the prognosis of BC patients. The forest plots show that EMT has the highest HR among various cancer hallmarks in the training cohort (a) and multiple cohorts calculated by meta-analysis (b). (c) GSEA plot illustrates that EMT is significantly enriched in BC samples than adjacent normal samples. (d) The heatmap exhibits the distribution of EMT scores and the patient information of grade, M stage, N stage, and T stage in the training cohort. (e) Violin plot displays that patients with higher T stage, N stage, and pathological grade have higher EMT scores. Kaplan–Meier survival curves depict that high-risk patients divided by EMT scores have worse OS (f), DSS (g), and DFI (h) compared with low-risk patients. HR: hazard ratio. BC: bladder cancer. OS: overall survival. DSS: disease-specific survival. DFI: disease-free interval. ; ; ns, no significance.