Research Article

Characterization of Epithelial-Mesenchymal Transition Identifies a Gene Signature for Predicting Clinical Outcomes and Therapeutic Responses in Bladder Cancer

Figure 5

Functional enrichment and immune cell infiltration analyses based on the gene signature. (a) Bar graph displays significantly enriched pathways in high-risk patients. Violin plots show higher immune score, stromal score, ESTIMATE score, and lower tumor purity in the high-risk patients compared with low-risk patients in the training (b) and merged validation cohorts (c). Box plots depict that CD8+ T cells, Tregs, M1 macrophages, and M2 macrophages are higher infiltrated and B naïve cells are lower infiltrated and in high-risk patients in both training (d) and merged validation (e) cohorts. ; ; .