Disease Markers

Epigenetic Biomarkers in Cancer


Status
Published

Lead Editor

1University of Sydney, Sydney, Australia

2Zhejiang University, Zhejiang, China

3National Chung Cheng University, Chia-Yi, Taiwan

4Chinese University of Hong Kong, Sha Tin, Hong Kong

5Medical University of Vienna, Vienna, Austria


Epigenetic Biomarkers in Cancer

Description

There has been an explosion of interest in the epigenetics of cancer in the past decade. DNA methylation is one of the major epigenetic mechanisms and it is a genetic feature better reflecting disease development and, consequently, has the potential to become more conclusive biomarker for detection and diagnosis of different diseases. The presence of small amounts of tumor DNA in cell free DNA (CFDNA) circulating in the plasma or serum of cancer patients was first demonstrated 30 years ago. Since then, overall plasma DNA concentration in cancer patients and genetic or epigenetic alterations specific to tumor DNA have been investigated in patients diagnosed with different types of cancer. However, the use of methylated DNA biomarkers is still not widely used in the clinic and further efforts to establish detection methods are required.

The ubiquity of DNA methylation changes has opened the way to a host of innovative diagnostic and therapeutic strategies. The status of DNA methylation is very stable, even in the circulation. Thus it can be assessed to monitor tumor-related processes. There is promising potential of DNA methylation as a diagnostic and prognostic marker for cancer patients due to the stability of circulating DNA. Development of noninvasive biomarker assays from patient samples would allow early diagnosis, prognosis prediction, and continuing assessment of disease progression and responses to treatments.

The present special issue aims to publish high-quality research articles as well as review contributions on a variety of topics related to epigenetic biomarkers detection in noninvasive clinical samples.

Potential topics include but are not limited to the following:

  • Types of epigenetic biomarkers and their significance
    • DNA methylation, circulating or noncirculating
    • MicroRNA and other noncoding RNA
    • Protein markers
  • Development of different nucleic acid methods using noninvasive samples
    • Blood serum or plasma
    • Urine
    • Stool
    • Sputum
  • DNA methylation detection in noninvasive samples
    • Blood serum or plasma
    • Urine
    • Stool
    • Sputum
  • Other nucleic acid (RNA and noncoding RNA) detections in noninvasive samples
  • Different disease methylation markers using noninvasive methods
  • DNA methylation in exfoliated cell in urine samples for urothelial/prostate cancer

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 4987103
  • - Editorial

Epigenetic Biomarkers in Cancer

Yuen Yee Cheng | Hong Chuan Jin | ... | Michael Grusch
  • Special Issue
  • - Volume 2017
  • - Article ID 2536187
  • - Research Article

SFRP Tumour Suppressor Genes Are Potential Plasma-Based Epigenetic Biomarkers for Malignant Pleural Mesothelioma

Yuen Yee Cheng | Ellie Mok | ... | Glen Reid
  • Special Issue
  • - Volume 2017
  • - Article ID 5472893
  • - Review Article

DNA Methylation Events as Markers for Diagnosis and Management of Acute Myeloid Leukemia and Myelodysplastic Syndrome

Geórgia Muccillo Dexheimer | Jayse Alves | ... | Ana Lucia Abujamra
  • Special Issue
  • - Volume 2017
  • - Article ID 3726595
  • - Review Article

DNA Methylation as a Noninvasive Epigenetic Biomarker for the Detection of Cancer

Catherine Leygo | Marissa Williams | ... | Yuen Yee Cheng
  • Special Issue
  • - Volume 2017
  • - Article ID 5745724
  • - Research Article

Identification of Biomarkers for Predicting Lymph Node Metastasis of Stomach Cancer Using Clinical DNA Methylation Data

Jun Wu | Yawen Xiao | ... | Xiaodong Zhao
  • Special Issue
  • - Volume 2017
  • - Article ID 7506976
  • - Research Article

Noncoding Centromeric RNA Expression Impairs Chromosome Stability in Human and Murine Stem Cells

David Y. L. Chan | Daniela Moralli | ... | Zoia L. Monaco
  • Special Issue
  • - Volume 2017
  • - Article ID 6309754
  • - Research Article

Association of Single-Nucleotide Polymorphisms in DC-SIGN with Nasopharyngeal Carcinoma Susceptibility

Sisi Li | Zhifang Lu | ... | Zhengbo Wei
  • Special Issue
  • - Volume 2017
  • - Article ID 7243968
  • - Review Article

Long Noncoding RNAs as Biomarkers in Cancer

Luka Bolha | Metka Ravnik-Glavač | Damjan Glavač
  • Special Issue
  • - Volume 2017
  • - Article ID 5189803
  • - Review Article

Can Mitochondria DNA Provide a Novel Biomarker for Evaluating the Risk and Prognosis of Colorectal Cancer?

Han Shuwen | Yang Xi | Pan Yuefen
Disease Markers
 Journal metrics
Acceptance rate34%
Submission to final decision88 days
Acceptance to publication43 days
CiteScore3.500
Impact Factor2.738
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