Disease Markers

Omics Landscape in Disease Biomarkers Discovery


Publishing date
19 Aug 2016
Status
Published
Submission deadline
01 Apr 2016

1Victor Babes National Institute of Pathology, Bucharest, Romania

2Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy

3University of Turin, Turin, Italy


Omics Landscape in Disease Biomarkers Discovery

Description

The accelerated domain of biomarker discovery is taking advantage of ever growing omics technologies. In the last years, we are facing an abundance of technologies that seek to discover the “golden biomarker.” The huge family of omics is constantly enlarging adding besides its old members, genomics, proteomics, and peptidomics, newer ones, epigenomics, transcriptomics, metabolomics, lipidomics, pharmacogenomics, interactomics, and chronomics, just to mention the most relevant newer members of the omics family.

Biomarker development relies on multidisciplinary efforts involving basic, translational, and clinical research. Multidisciplinary effort is crucial for rational discovery of protein/gene biomarkers that can cover complex processes such as tumorigenesis. Biomarker discovery goes through laborious individual phases, such as biomarker candidate identification, verification, and validation. In all these phases, various omics technologies take the lead. When characterizing thousands to tens of thousands of proteins, mass spectrometry, multiplexed assays, and protein microarrays are the key technological players. For genomic studies, technological platforms of gene microarrays, next-generation sequencing, and mass spectrometry generate tumor-associated genes and potential biomarkers. Complementary omics approaches for selection of biomarker candidates should focus on multiple proteomic/genomic/metabolomic targets. These multifaceted targets could better explain complex disease mechanisms.

We invite investigators to contribute review and original papers describing recent findings in omics field that are put in use for biomarkers discovery in cancer.

Potential topics include, but are not limited to:

  • Proteomics in biomarker discovery in skin cancer, brain cancer, and other types of cancer
  • Signaling events as biomarkers in cancer
  • Advances in genomics for cancer biomarkers discovery
  • Translational omics, reaching clinical laboratory tests
  • Microarrays as high-throughput tools for biomarkers discovery
  • Bioinformatics, main tool for advancing biomarker discovery
  • Lab-on-a-chip in medical omics
  • Overview of omics technology in drug testing and in personalized medicine
  • Nanoparticles for biomarker discovery
  • Proteomics in physiological and pathological conditions

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 4068252
  • - Editorial

Omics Landscape in Disease Biomarkers Discovery

Monica Neagu | Caterina Longo | Simone Ribero
  • Special Issue
  • - Volume 2016
  • - Article ID 9602472
  • - Review Article

Proteomic Approaches to Biomarker Discovery in Cutaneous T-Cell Lymphoma

Alexandra Ion | Iris Maria Popa | ... | Daniel Boda
  • Special Issue
  • - Volume 2016
  • - Article ID 3185232
  • - Research Article

Proteomic Biomarkers Panel: New Insights in Chronic Kidney Disease

Simona Mihai | Elena Codrici | ... | Cristiana Tanase
  • Special Issue
  • - Volume 2016
  • - Article ID 9406319
  • - Review Article

CEACAM1: Expression and Role in Melanocyte Transformation

Gabriela Turcu | Roxana Ioana Nedelcu | ... | Sabina Andrada Zurac
  • Special Issue
  • - Volume 2016
  • - Article ID 4517492
  • - Review Article

From Normal Skin to Squamous Cell Carcinoma: A Quest for Novel Biomarkers

Vlad Voiculescu | Bogdan Calenic | ... | Constantin Caruntu
  • Special Issue
  • - Volume 2016
  • - Article ID 9831237
  • - Review Article

Gene Expression and Proteome Analysis as Sources of Biomarkers in Basal Cell Carcinoma

Mihai Lupu | Constantin Caruntu | ... | Daniela Elena Costea
  • Special Issue
  • - Volume 2016
  • - Article ID 3625279
  • - Research Article

Expression Profile of p53 and p21 in Large Bowel Mucosa as Biomarkers of Inflammatory-Related Carcinogenesis in Ulcerative Colitis

Cristiana Popp | Luciana Nichita | ... | Radu Bogdan Mateescu
  • Special Issue
  • - Volume 2016
  • - Article ID 1243819
  • - Review Article

Inflammatory Biomarkers Profile as Microenvironmental Expression in Keratoconus

Catalina Ionescu | Catalina Gabriela Corbu | ... | Liliana-Mary Voinea
  • Special Issue
  • - Volume 2016
  • - Article ID 9214056
  • - Review Article

Tyrosine Kinase Receptor Landscape in Lung Cancer: Therapeutical Implications

A. Quintanal-Villalonga | Luis Paz-Ares | ... | S. Molina-Pinelo
  • Special Issue
  • - Volume 2016
  • - Article ID 3851054
  • - Review Article

Circulating MicroRNAs as Potential Molecular Biomarkers in Pathophysiological Evolution of Pregnancy

Dragos Cretoiu | Jiahong Xu | ... | Sanda Maria Cretoiu
Disease Markers
 Journal metrics
Acceptance rate34%
Submission to final decision88 days
Acceptance to publication43 days
CiteScore3.500
Impact Factor2.738
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