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Biomarkers for Renal Autoimmunity: The role of Effector Cells

Call for Papers

Systemic autoimmune diseases are characterized by various organ manifestations including the skin, heart, lung, and hematologic disorders. The involvement of kidneys is a frequent and severe manifestation which determines the mortality and long term outcome of systemic autoimmune diseases.

Autoantibodies against nuclear, cytoplasmatic, and glomerular antigens are a hallmark of systemic autoimmune diseases affecting the kidney. B-cells as a source of autoantibodies and also into-kidney-migrating-activated effector T-cells are thought to be crucial for the development of autoimmune glomerulonephritis. There is growing evidence that a lack of regulation (Tregs and Bregs) promotes these autoimmune responses. T-cell mediated inflammation, that is, via IL-17, seems to be crucial for the pathogenesis of autoimmune diseases. These effector cells could also serve as therapeutical target as well as new biomarkers.

The prevention and detection of autoimmune mediated kidney disease are important clinical issues. In this special issue we want to encourage authors to submit work elucidating the role of activated B- and T-cells as well as dysfunctional T- and B-cell regulation in systemic autoimmune diseases with special regard to renal involvement and kidney injury. New insights could improve target therapies and the monitoring of disease activity.

Potential topics include but are not limited to the following:

  • Activation and costimulation of CD4+ T-cells
  • Cytotoxic T-cells
  • T-helper cells (i.e., Th17-cells)
  • B-cell hyperactivity
  • Regulatory T-cells and B-cells
  • Cell migration and kidney inflammation
  • Urinary biomarker for disease activity

Authors can submit their manuscripts through the Manuscript Tracking System at

Submission DeadlineFriday, 1 June 2018
Publication DateOctober 2018

Papers are published upon acceptance, regardless of the Special Issue publication date.

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