Disease Markers

Biomarkers and Therapeutic Targets of Diabetes Mellitus and its Complications


Publishing date
01 Dec 2022
Status
Published
Submission deadline
22 Jul 2022

Lead Editor

1Nanjing University of Chinese Medicine, Nanjing, China

2Case Western Reserve University, Cleveland, USA


Biomarkers and Therapeutic Targets of Diabetes Mellitus and its Complications

Description

The number of people with diabetes rose from 108 million in 1980 to 422 million in 2014. In 2019, an estimated 1.5 million deaths were directly caused by diabetes. There are a number of diabetic complications. Among them, the most prevalent microvascular complications are kidney disease, blindness, and amputations, with current therapies only slowing disease progression. Heart attacks, stroke, neuropathy, skin and foot diseases are also serious complications of diabetes.

Biomarkers and intracellular and extracellular signaling pathways have important roles in the diagnosis and prognosis of diabetes and its complications, as well as identifying individuals who exhibit a high risk for diabetes development. For example, alanine aminotransferase, uric acid and vitamin D are closely related to the occurrence of T2DM (type 2 diabetes mellitus). Albuminuria strongly predicts the progression of diabetic kidney disease (DKD). In addition, the rapidly developed genomics, transcriptomics, proteomics, metabolomics, and immunology provided new ideas and platforms for the research of diabetes mellitus in recent years.

The aim of this Special Issue is to invite authors to submit original research and review articles that provide novel findings of biomarkers as well as cellular and molecular mechanisms involved in the field of diabetes mellitus and its complications. Insights in the areas of effective targeted theranostic strategies and other investigating challenges and opportunities associated with targeting therapy are also welcome.

Potential topics include but are not limited to the following:

  • Novel biomarkers and targets of diagnosis and treatment for diabetes mellitus and its complications
  • The functions and roles of diabetic biomarkers
  • Intracellular and extracellular signaling pathways and small molecule inhibitors in diabetes mellitus
  • The molecular mechanism of vascular aging in diabetes mellitus
  • Regulatory roles of non-coding RNAs and exosomes in diabetes mellitus
  • The study of single-cell RNA sequencing, bulk RNA sequencing, and spatial transcriptomics for diabetes mellitus
  • Regulatory roles of immune cells for diabetes mellitus
  • Animal models for in vivo imaging and quantification analysis in diabetes mellitus

Articles

  • Special Issue
  • - Volume 2022
  • - Article ID 1927688
  • - Research Article

Exploring Anti-Type 2 Diabetes Mellitus Mechanism of Gegen Qinlian Decoction by Network Pharmacology and Experimental Validation

Weiping Bao | Hongping Sun | ... | Yaofu Fan
  • Special Issue
  • - Volume 2022
  • - Article ID 4231535
  • - Research Article

Ultrasonography Combined with Blood Biochemistry on the Early Diagnosis of Diabetic Kidney Disease

Jing Lin | Guangde Liu | ... | Youhua Xu
  • Special Issue
  • - Volume 2022
  • - Article ID 3664931
  • - Research Article

Expression of Adenosine Deaminase and NLRP3 Inflammasome in Tuberculous Peritonitis and Their Relationship with Clinical Efficacy

Hongwei Su | Guorong Yan | ... | Lingdi Li
  • Special Issue
  • - Volume 2022
  • - Article ID 7285639
  • - Research Article

Effect of Multidisciplinary Team Continuous Nursing on Glucose and Lipid Metabolism, Pregnancy Outcome, and Neonatal Immune Function in Gestational Diabetes Mellitus

Shuping Qi | Yanmei Dong
  • Special Issue
  • - Volume 2022
  • - Article ID 7593750
  • - Research Article

A Deep Learning Model Incorporating Knowledge Representation Vectors and Its Application in Diabetes Prediction

He Xu | Qunli Zheng | ... | Yimu Ji
  • Special Issue
  • - Volume 2022
  • - Article ID 3150380
  • - Research Article

Hepatic Steatosis Index and the Risk of Type 2 Diabetes Mellitus in China: Insights from a General Population-Based Cohort Study

Xintian Cai | Jing Gao | ... | Nanfang Li
  • Special Issue
  • - Volume 2022
  • - Article ID 7979500
  • - Research Article

Expression of miR-155 in Serum Exosomes in Children with Epilepsy and Its Diagnostic Value

Ya Liu | Gang Yu | ... | Yong-Xia Zhang
  • Special Issue
  • - Volume 2022
  • - Article ID 7383745
  • - Research Article

A Randomized Study on the Effect of Metformin Combined with Intensive-Exercise Diet Therapy on Glucose and Lipid Metabolism and Islet Function in Patients with Renal Cell Carcinoma and Diabetes

Yang Liu | Ling-Ling Meng | ... | Rui-Hua An
  • Special Issue
  • - Volume 2022
  • - Article ID 1417104
  • - Research Article

Application of Endoscopic Ultrasound Combined with Multislice Spiral CT in Diagnosis and Treatment of Patients with Gastrointestinal Eminence Lesions

Jie Xiong | Jie Jiang | ... | Shuchang Xu
  • Special Issue
  • - Volume 2022
  • - Article ID 7251450
  • - Research Article

Pharmacological Mechanism of Ganlu Powder in the Treatment of NASH Based on Network Pharmacology and Molecular Docking

Rui Gao | Xiaobo Zhang | ... | Tao Shen

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