Table of Contents
Dataset Papers in Pharmacology
Volume 2013 (2013), Article ID 169357, 3 pages
http://dx.doi.org/10.7167/2013/169357
Dataset Paper

Antitumor Activity of Leaves from Hyptis mutabilis (A. Rich.) Briq. (Lamiaceae) in Mice Bearing Tumor

1Department of Antibiotics, Federal University of Pernambuco, 50670-091 Recife, PE, Brazil
2Department of Physiology and Pharmacology, Federal University of Ceará, 60430-270 Fortaleza, CE, Brazil

Received 27 March 2012; Accepted 11 April 2012

Academic Editors: S. Kishioka and E. Küpeli Akkol

Copyright © 2013 Rafael Matos Ximenes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The Hyptis genus has more than 400 species, many of them being used in folk medicine to treat several conditions. Some anticancer compounds have been isolated from plants of this genus, and for that reason we decided to investigate the potential in vivo antitumor activity of extracts of leaves of Hyptis mutabilis with different polarities (hexane, methanol, water, and hot water) against two mice tumors: sarcoma 180 and Ehrlich solid tumor. Phytochemical analysis revealed strong presence of steroids, saponins, flavonoids (mainly dihydroflavanols), and catechins. Acute toxicity was perfomed according to the up-and-down method showing LD50 values ranging from 100 up to 2500 mg/kg. Antitumor activity was investigated using 10% of the LD50 for each extract. Methotrexate was used as positive control. Both aqueous extracts showed strong inhibition of tumor growth with values up to 70% of inhibition growth for sarcoma 180. Ehrlich solid tumor was only slight inhibited by hexane extract (38.6%). In conclusion, the aqueous extracts of H. mutabilis showed promising results against sarcoma 180 mice tumor.