Table of Contents
Dataset Papers in Pharmacology
Volume 2013, Article ID 243949, 5 pages
http://dx.doi.org/10.7167/2013/243949
Dataset Paper

In Vivo Antioxidant Activity of Topical Cream of Cassia tora L. Leaves Extract

1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Jodhpur National University, Jodhpur 342001, Rajasthan, India
2Department of Pharmaceutics, Rajasthan Pharmacy College, Jaipur 303006, Rajasthan, India
3Department of Pharmacology, School of Pharmaceutical Sciences, Jaipur National University, Jaipur 302025, Rajasthan, India
4Department of Chemistry, Shree Dhanvantary Pharmaceutical Analysis and Research Centre, Kim, Surat 394110, Gujarat, India

Received 5 April 2012; Accepted 29 April 2012

Academic Editors: Ricardo Garay and Thaís Posser

Copyright © 2013 V. Gupta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. The aim of study was to determine the in vivo antioxidant activity of newly formulated O/W cream of methanolic extract of Cassia tora L. leaves. Methods. Oil in water (O/W) creams (0.05%, 0.1%, and 0.2%), cream base, methanolic extract of C. tora L. leaves (CTM), and standard (0.05% tretinoin cream) were screened for in vivo antioxidant activity. The ultraviolet- (UV-) B-induced rats were treated with different standard, O/W creams, cream base, and methanolic extract of Cassia tora L. leaves (CTM). The parameters like lipid peroxidation (LPO), reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) levels were assessed. Results. The result of acute dermal toxicity shows that the creams were safe up to 2000 mg/kg (topically). Exposure of ultraviolet light of medium wave (UV-B light) decreased the level of GSH, CAT, and SOD and increased the LPO level. Concluding Remarks. We conclude that topical O/W creams of C. tora L. prevent the oxidative stress induced in rats by exposure to UV-B light by virtue of its in vivo antioxidant property, and these findings help to understand the mechanism of the antipsoriatic activity of O/W creams of C. tora L. in UV-B-induced psoriasis in the rat.