Table of Contents
Dataset Papers in Science
Volume 2014, Article ID 105312, 4 pages
Dataset Paper

The Equine CD4+ Lymphocyte Proteome

1Institute for Animal Physiology, Department of Veterinary Sciences, Ludwig Maximilians University Munich, Veterinärstraße 13, 80539 Munich, Germany
2Research Unit Protein Sciences, Helmholtz Center Munich, German Research Center for Environmental Health GmBH, Ingolstaedter Landstraße 1, 85764 Neuherberg, Germany
3Center for Ophthalmology, Institute for Ophthalmic Research, Eberhard Karls University of Tübingen, Röntgenweg 11, 72076 Tübingen, Germany

Received 1 April 2014; Accepted 27 July 2014; Published 4 September 2014

Academic Editor: Remond Fijneman

Copyright © 2014 Roxane L. Degroote et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


CD4+ T cells are key players in immunology and disease pathology, including relapsing autoimmune uveitis. Equine recurrent uveitis is the only spontaneous animal model for this disease in man. Knowledge about the CD4+ cell proteome is crucial for studies on possible changes in proteome expression of CD4+ effector cells in disease. For this purpose, we generated a reference dataset of the equine CD4+ cell proteome by sorting equine CD4+ lymphocytes followed by analysis of whole cell lysate as well as membrane protein fraction using mass spectrometry.