Diagnostic Pitfalls in Newborns and Babies with Blisters and Erosions

Table 1

Differential diagnosis of erosions and blisters in the neonate and young 𝑐ℎ𝑖𝑙𝑑^∗.

Inherited or congenital disorders	Acquired disorders
Epidermolysis bullosa hereditaria—all types (simplex, junctional, dystrophic)	Immunobullous disorders
Ichthyosis bullosa of Siemens	Epidermolysis bullosa acquisita
Netherton syndrome	Linear IgA dermatosis
Congenital peeling skin syndromes	Bullous pemphigoid
Pachyonychia congenita	Cicatricial pemphigoid
Kindler’s syndrome	Pemphigus
Congenital porphyria	Infectious diseases
Acrodermatitis enteropathica	Herpes simplex
Incontinentia pigmenti	Bullous impetigo
Ectodermal dysplasia	Staphylococcal scalded skin syndrome
AEC syndrome (Hay-Wells syndrome)	Congenital lues (pemphigus syphiliticus)
Ectodermal dysplasia with plakophilin 1 deficiency	Other bacterial, viral or fungal infections
Congenital absence of skin (cutis aplasia)	Other diseases or conditions
Congenital erosive dermatosis with reticulate supple scarring	Bullous mastocytosis
Mendes da Costa syndrome	Behcet disease
Shabbir’s syndrome (laryngo-onychocutaneous syndrome)	Traumatic blisters (sucking, other)
Epidermolytic hyperkeratosis (bullous ichthyosiform erythroderma)	Toxic epidermal necrolysis

^∗Modified by Eady et al. [2].