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Dermatology Research and Practice
Volume 2009, Article ID 679010, 3 pages
Clinical Study

Desmoplastic Melanoma: Report of 5 Cases

1Department of Dermatology, University Hospital Spedali Civili, 25123 Brescia, Italy
2Department of Dermatology, Casa di Cura Poliambulanza, 25123 Brescia, Italy
3Department of Pathology I, University Hospital Spedali Civili, 25123 Brescia, Italy

Received 14 May 2009; Revised 8 July 2009; Accepted 15 September 2009

Academic Editor: Giuseppe Argenziano

Copyright © 2009 A. M. Manganoni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. The clinical presentation of desmoplastic melanoma is often challenging. We report the experience of the Melanoma Unit of Spedali Civili University Hospital of Brescia, Italy. Method. Study subjects were drawn from 1770 patients with histologica confirmed melanoma. Within this group, desmoplastic melanoma developed in 5 patients. For each diagnosed melanoma, histological characteristics, treatment, and outcomes were evaluated. Results. Of the 5 patients described in this study, 2 were males and 3 females. The average age was 62.4 years ranging from 56 to 68 years. Breslow thickness ranged from 2.1 to 12 mm with a mean thickness of 5.8 mm. Primary treatment of 5 patients included a wide local excision of their primary lesions. Conclusions. Desmoplastic melanoma is a rare neoplasm which clinically may mimic other tumours or cutaneous infiltrate of uncertain significance. The diagnosis is hiastopathological and radical resection is necessary.