Review Article
Angiogenesis and Progression in Human Melanoma
Table 1
Molecular targets of antiangiogenic drugs.
| Category | Molecular Targets | Name |
| Angiogenic growth factors and their receptors | VEGF | Bevacizumab | Tyrosine kinase receptors | Sorafenib | VEGF receptors | PTK/ZK | DC101 |
| Receptors for extracellular matrix, integrins | Integrin v3 | Vitaxin (MEDI-52) | v3/v5 | Cilengitide | (EMD 121974) |
| Components of extracellular matrix and proteases | MMPs | Batimastat | Marimastat | Extracellular matrix | Endostatin |
| Complex mechanism of action | Angiogenesis inhibitors and immunomodulators | Thalidomide | Lenalidomide | Cyclooxygenase-2 | Celecoxib |
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