Dermatology Research and Practice / 2010 / Article / Tab 1

Review Article

Angiogenesis and Progression in Human Melanoma

Table 1

Molecular targets of antiangiogenic drugs.

CategoryMolecular TargetsName

Angiogenic growth factors and their receptorsVEGFBevacizumab
Tyrosine kinase receptorsSorafenib
VEGF receptorsPTK/ZK
DC101

Receptors for extracellular matrix, integrinsIntegrin v 3Vitaxin (MEDI-52)
v 3/ v 5Cilengitide
(EMD 121974)

Components of extracellular matrix and proteasesMMPsBatimastat
Marimastat
Extracellular matrixEndostatin

Complex mechanism of actionAngiogenesis inhibitors and immunomodulatorsThalidomide
Lenalidomide
Cyclooxygenase-2Celecoxib

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