Therapeutic Improvement of Scarring: Mechanisms of Scarless and Scar-Forming Healing and Approaches to the Discovery of New Treatments
Figure 3
Comparison of Scarring at the Macroscopic and Microscopic Levels between experimental incisional wound models in pre-clinical species and humans. Scarring response in mice 70 days following a 1 cm full thickness incisional wound on the dorsum at the macroscopic ((a) arrowheads indicate ends of original wound) and microscopic ((b) arrowheads indicate scar) levels. Scarring response in rats 84 days following a 1 cm full thickness incisional wound on the dorsum at the macroscopic ((c) arrowheads indicate ends of original wound) and microscopic ((d) arrowheads indicate scar) levels. Scarring response in pigs 168 days following a 1 cm full thickness incisional wound on the dorsum at the macroscopic ((e) arrowheads indicate ends of original wound) and microscopic ((f) arrowheads indicate scar) levels. Scarring response in humans 365 days following a 1 cm full thickness incisional wound on the inner aspect of the upper arm at the macroscopic ((g) arrowheads indicate ends of original wound) and microscopic ((h) arrowheads indicate scar) levels.
