Table of Contents Author Guidelines Submit a Manuscript
Dermatology Research and Practice
Volume 2010, Article ID 638051, 4 pages
Research Article

Effects of Olopatadine Hydrochloride, a Histamine H 𝟏 Receptor Antagonist, on Histamine-Induced Skin Responses

Department of Dermatology, Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology, 67 Asahimachi, Kurume, Fukuoka 830-0011, Japan

Received 17 March 2010; Revised 7 July 2010; Accepted 23 August 2010

Academic Editor: Thilo Gambichler

Copyright © 2010 Takashi Hashimoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Hide, M. Furue, Z. Ikezawa et al., “Guidelines for the diagnosis and treatment of urticaria and angioedema,” The Japanese Journal of Dermatology, vol. 115, pp. 703–715, 2005 (Japanese). View at Google Scholar
  2. M. Furue, “Distress and demand of patients with urticaria for QOL and medical treatments,” Rinsho Derma, vol. 45, no. 7, pp. 789–794, 2003 (Japanese). View at Google Scholar
  3. A. Urae, M. Okada, S. Irie et al., “Effects of fexofenadine hydrochloride on psychomotor performance—comparison of impaired performance of word processor by fexofenadine hydrochloride with that by d-chlorpheniramine maleate in healthy volunteers,” Japanese Journal of Clinical Pharmacology and Therapeutics, vol. 31, pp. 649–658, 2000. View at Google Scholar
  4. M. Tsunoo, S. Momomura, M. Masuo et al., “ Phase I clinical study on KW-4679, an antiallergic drug -safety and pharmacokinetics in the single and repeated administration study to healthy subjects,” Kiso-to-Rinsho, vol. 29, pp. 4129–4147, 1995 (Japanese). View at Google Scholar
  5. H. Yokota, H. Mizuuchi, T. Maki, K. Banno, and T. Sato, “Phase I study of TAU-284—single oral administration in healthy male volunteers,” Journal of Clinical Therapeutics & Medicines, vol. 13, pp. 1137–1153, 1997. View at Google Scholar
  6. “Package insert of Allegra®tablets ” (Japanese).
  7. K. Morita, T. Koga, Y. Moroi, K. Urabe, and M. Furue, “Rapid effects of olopatadine hydrochloride on the histamine-induced skin responses,” Journal of Dermatology, vol. 29, no. 11, pp. 709–712, 2002. View at Google Scholar · View at Scopus
  8. H. Takahashi, Y. Zhang, and E. Morita, “Evaluation of the antihistamine effects of olopatadine, cetirizine and fexofenadine during a 24 h period: a double-blind, randomized, crossover, placebo-controlled comparison in skin responses induced by histamine iontophoresis,” Archives of Dermatological Research, vol. 300, no. 6, pp. 291–295, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. Y. Matsumoto, J. Funahashi, K. Mori, K. Hayashi, and H. Yano, “The noncompetitive antagonism of histamine H1 receptors expressed in chinese hamster ovary cells by olopatadine hydrochloride: its potency and molecular mechanism,” Pharmacology, vol. 81, no. 3, pp. 266–274, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. K. Yanai and M. Tashiro, “The physiological and pathophysiological roles of neuronal histamine: an insight from human positron emission tomography studies,” Pharmacology and Therapeutics, vol. 113, no. 1, pp. 1–15, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus