Table 2: Observed differences between fetal and adult fibroblasts.

Fetal FibroblastAdult Fibroblast

alpha-SMA
(serum containing cultures)
LowHigh

In-vitro collagen
contraction
LessMore

Hyaluronic acid
(HA)
Increased HA synthesis
irrespective of cell density
Decreased HA synthesis
as cell density increases
Hyaluronic acid
receptor
HighLow

Proinflammatory
cytokines
IL-6LowHigh
IL-8LowHigh

CCT-subunits
CCT-etaLowHigh
CCT-betaNo changeNo change