379173.fig.004a
(a)
379173.fig.004b
(b)
Figure 4: Epidermal pigmentation reduction. (a) Basal melasma skin biopsy, (b) skin biopsy posttreated with niacinamide. (Fontana Masson, original magnification 40x). Below is shown the measured positive areas for melanin using a computer-assisted image analysis program.