A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma
Epidermal pigmentation reduction. (a) Basal melasma skin biopsy, (b) skin biopsy posttreated with niacinamide. (Fontana Masson, original magnification 40x). Below is shown the measured positive areas for melanin using a computer-assisted image analysis program.
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