Molecular Nevogenesis

Table 1

Congenital melanocytic nevi.

Study	Size studied	NRAS	BRAF	Specimen selection
Carr and Mackie 1994 [3]	Total^a	12 of 43	n/a	Present before age 2 per parent testimony
Jafari et al. 1995 [4]	Total^a	1 of 1	n/a	Histology alone
Papp et al. 1999 [5]	Total	10 of 18		Histology alone
	Small	2 of 3	n/a
	Medium	8 of 15
Pollock et al. 2003 [6]	Total^a	n/a	6 of 7	Histology alone
Yazdi et al. 2003 [7]	Total^a	n/a	6 of 13	Histology alone
Papp et al. 2005 [8]	Total^a	n/a	7 of 18	Histology alone
Da Raeve et al. 2006 [9]	Total	n/a	0 of 36	Documented in medical records at birth
	Medium		0 of 10
	Large		0 of 26
Ichii-Nakata et al. 2006 [10]	Total	9 of 20	39 of 62	Documented in medical records at birth per parent testimony
	Small	n/a	33 of 42
	Medium	9 of 20	6 of 20
Bauer et al. 2007 [11]	Total^b	26 of 32	0 of 32	Documented in medical records at birth
Bauer et al. 2007 [11]	Total^c,d	7 of 28	20 of 28	Histology alone
Wu et al. 2007 [12]	Total	n/a	26 of 34	Documented in medical records at birth
	Small		20 of 25
	Large		6 of 9
	Total	19 of 27	6 of 27	Documented in medical records at birth
Dessars et al. 2009 [13]	Medium	1 of 3	1 of 3
	Large	18 of 24	5 of 24^e
Totals	Total	77 of 141 (54.6%)	90 of 229 (39.3%)
	Small	n/a	53 of 67 (79.1%)
	Medium and Large	62 of 94 (65.9%)	18 of 124 (14.5%)

(a) Size of specimens not specified; (b) all specimens either medium or large CMN; (c) all specimens small CMN; (d) not included in totals because purposely selected for acquired nevi with congenital patterns; and (e) two of the five represent chromosomal translocation involving BRAF.