Molecular Nevogenesis

Table 2

Spitz nevi.

Study	HRAS	NRAS	BRAF	Histological Subtypes Included
Bastian et al. 1999 [18]	4^a of 17	n/a	n/a	Typical Spitz nevi
Bastian et al. 2000 [19]	12^b of 102	n/a	n/a	Typical Spitz nevi
Yazdi et al. 2003 [7]^c	n/a	n/a	0 of 69	Typical Spitz nevi
Palmedo et al. 2004 [20]^c	n/a	n/a	0 of 21	Typical Spitz nevi
Mihic-Probst et al. 2004 [21]^c	n/a	n/a	0 of 20	Typical Spitz nevi
Saldanha et al. 2004 [22]^d	n/a	1 of 16	0 of 26	Typical Spitz nevi
Gill et al. 2004 [23]^e	n/a	n/a	0 of 30	Typical Spitz nevi
Turner et al. 2005 [24]^d	n/a	n/a	0 of 24	Typical Spitz nevi
Van Dijk et al. 2005 [17]^e	6^f of 30	0 of 30	0 of 30	Typical and Atypical Spitz nevi
Fullen et al. 2006 [25]	n/a	1 of 48	10^g of 48	Spitz nevi and nevi of Reed
La Porta et al. 2006 [26]	n/a	n/a	8 of 8	Reed nevi only
Takata et al. 2007 [27]	0 of 12	0 of 12	0 of 12	Typical Spitz nevi
Da Forno et al. 2009 [28]	2^h of 19	2^i of 22	2^9 of 22	Typical and Atypical Spitz nevi
Emley et al. 2010 [29]	n/a	0 of 20	1 of 20	Typical and Atypical Spitz nevi
Total (%)	24 of 180 (13.3%)	4 of 98 (4.1%)	21 of 330 (6.4%)

(a) All represent copy number increases of chromosome 11p; (b) all twelve represent copy number increases of chromosome 11p, eight of which contain mutations; (c) scalpel used for microdissection of melanocytes from fixed tissue; (d) did not utilize microdissection techniques to isolate melanocytes; (e) laser capture used for microdissection of melanocytes from fixed tissue; (f) two of the six HRAS mutations occurred in atypical nevi; (g) five of the ten BRAF mutations occurred in atypical inflammatory lesions that likely represented dysplastic nevi; (h) one of the two occurred in an atypical nevus; and (i) one of the two occurred in an atypical nevus with both BRAF and NRAS mutations.