Differential Downregulation of E-Cadherin and Desmoglein by Epidermal Growth Factor
Figure 5
Cadherins do not cointernalize with the EGF receptor. SCC 12F cells were treated with 20 nM EGF for 30 minutes, fixed, and probed for EGF receptor (green) or junctional cadherin (red). White arrows indicate the internalized EGF receptor in the cytoplasm while both junctional cadherins, desmoglein-2 (upper panel), and E-cadherin (lower panel) remain at the cell surface 30 minutes post EGF treatment.
