miRNAs and Melanoma: How Are They Connected?

Table 2

miRNAs expression changes related with melanoma progression and their targets.

miRNAs	mRNA target	Consequence	Reference
miR-196a decrease	HOX-C8	cadherin-11 expression modification	[55]
miR-200a or miR-200c super-expression	—	increase the invasive capacity	[63]
miR-148 diminished	MITF	contributes to malignant transformation	[69]
VNTR pri-miRNA-137 (miR-137)	MITF	contributes to malignant transformation	[70]
miR-182 gene locus amplification	MITF and FOXO3	Increased of invasive and survival capacity and enhances metastatic potential	[68]
miR-211 decrease	KCNMA1	contribute with malignant metastatic phenotype	[71]
miRNA-193b decrease	CYCLIN D1	increased cell proliferation	[74]
miR-let7b decrease	CYCLIN D1 and Bsg	high proliferation rate	[61, 81]
miR-205 decrease	E2F1	high proliferation rate	[79]