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Dermatology Research and Practice
Volume 2014, Article ID 596564, 6 pages
http://dx.doi.org/10.1155/2014/596564
Research Article

Expression of Maspin and Ezrin Proteins in Periocular Basal Cell Carcinoma

1Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Ophthalmology Department, Shiraz University of Medical Sciences, Shiraz, Iran
3Pathology Department, Liver Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Received 4 July 2014; Accepted 28 November 2014; Published 15 December 2014

Academic Editor: Jane M. Grant-Kels

Copyright © 2014 Mansooreh Bagheri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The aim of this study was to investigate maspin and ezrin expression in different subtypes of periocular basal cell carcinoma (BCC). Methods. Tissue samples from 43 patients with periocular BCC. Our cases were comprised of 10 morpheaform, 25 nodular, and 8 adenoid type BCCs. Immunohistochemical staining for maspin and ezrin was performed by Envision detection system. Results. There was no difference between different subtypes of BCC in maspin expression regarding positivity, intensity, and pattern of expression. Ezrin was expressed in all subtypes of BCC but the intensity was significantly higher in morpheaform BCC compared to nodular and adenoid types ( and , resp.); ninety percent of morpheaform samples showed strong ezrin intensity, while this strong intensity was only present in 25% and 12% of adenoid and nodular subtypes, respectively. There was no correlation between age, sex, or tumor margin involvement and expression of neither maspin nor ezrin. There was no correlation between maspin and ezrin expression except in nodular type, in which an inverse correlation was found . Conclusion. Ezrin is expressed intensely in morpheaform BCC of periocular region. Further studies are needed to show the significance of this finding in prognosis of morpheaform BCC.