Pathogenesis of Chronic Urticaria: An Overview

Table 2

Cytokine, chemokine, and adhesion molecule expression: urticarial wheals, uninvolved skin, and healthy control subjects [4].

	Urticarial wheal	Uninvolved skin	Normal healthy controls
Cytokines
Interferon gamma	High expression	Significantly low expression	Not expressed
Interleukin-4	High expression	Significantly low expression	Not expressed
Interleukin-5	High expression	Significantly low expression	Not expressed
Interleukin-8	Moderate expression	Moderate expression	Not expressed
Chemokines
C X C R 3/CC R 3	Expression similar to control skin	High expression	Expression similar in lesional and healthy control skin
Adhesion molecules
Cellular adhesion molecule	High expression	Intense expression	Significant expression