TY - JOUR A2 - Furue, Masutaka AU - Chanprapaph, K. AU - Vachiramon, V. AU - Rattanakaemakorn, P. PY - 2014 DA - 2014/03/02 TI - Epidermal Growth Factor Receptor Inhibitors: A Review of Cutaneous Adverse Events and Management SP - 734249 VL - 2014 AB - Epidermal growth factor inhibitors (EGFRI), the first targeted cancer therapy, are currently an essential treatment for many advance-stage epithelial cancers. These agents have the superior ability to target cancers cells and better safety profile compared to conventional chemotherapies. However, cutaneous adverse events are common due to the interference of epidermal growth factor receptor (EGFR) signaling in the skin. Cutaneous toxicities lead to poor compliance, drug cessation, and psychosocial discomfort. This paper summarizes the current knowledge concerning the presentation and management of skin toxicity from EGFRI. The common dermatologic adverse events are papulopustules and xerosis. Less common findings are paronychia, regulatory abnormalities of hair growth, maculopapular rash, mucositis, and postinflammatory hyperpigmentation. Radiation enhances EGFRI rash due to synergistic toxicity. There is a positive correlation between the occurrence and severity of cutaneous adverse effects and tumor response. To date, prophylactic systemic tetracycline and tetracycline class antibiotics have proven to be the most effective treatment regime. SN - 1687-6105 UR - https://doi.org/10.1155/2014/734249 DO - 10.1155/2014/734249 JF - Dermatology Research and Practice PB - Hindawi Publishing Corporation KW - ER -