Type I Interferons: Key Players in Normal Skin and Select Cutaneous Malignancies
Effect of type I Interferon on cutaneous squamous cell carcinoma.
Type of effect
Description of effect
IFN- has greater antiproliferative effect than IFN- in SCL-1 cells. IFN- induced a partial G1/0 arrest in SRB12-p9 cells. SCC-12B.2 cell line is less sensitive than normal keratinocytes to growth inhibitory effects of IFNs-
Compared to normal skin, there was decreased staining intensity for ISGF3 proteins in not only specimens of human skin SCCs but also specimens of actinic keratoses. Cell growth inhibitory effect of IFN-α requires an intact STAT2 protein.