Ischaemic Preconditioning Suppresses Necrosis of Adipocutaneous Flaps in a Diabetic Rat Model Regardless of the Manner of Preischaemia Induction

Figure 3

Noninvasive IP suppressed tissue necrosis in diabetic skin flaps. Group A: healthy controls (%); Group B: STZ induced diabetic controls (%); Group F: pharmacologically induced IP using the nitric oxide donor Spermine (%); Group G: nitric oxide synthase blocker L-NAME (%); Group H: nitric oxide synthases blocker L-NAME + tourniquet (%); Group I: 30 min preischaemic nitric oxide donor (%); Group J: postischaemic nitric oxide donor (%); results are presented as mean ± SEM. was considered statistically significant.